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Association<\/em>\uff0c<em>JAMA<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a63.1\uff09\u5168\u6587\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u98a8\u96aa\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e37%\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5c0d\u6bd4\u55ae\u7d14\u5316\u7642\u5ef6\u9577\u4e8613.2\u500b\u6708\uff0c\u5f9e8.2\u500b\u6708\u63d0\u5347\u523021.4\u500b\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u8a72\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u7684\u60a3\u8005\u53ef\u7372\u5f97\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u9577\u7684\u6301\u7e8c\u7de9\u89e3\u6642\u9593\uff08DoR\uff09\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u9054\u523026.7%\uff0c\u4e14\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u9577\u671f\u751f\u5b58\u96a8\u8a2a\u8cc7\u6599\u57282024\u5e74ASCO\u5e74\u6703\u5c55\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u7d445\u5e74\u751f\u5b58\u7387\u9054\u523052.0%\u3002<\/p>\n\n\n\n<p>POLARIS-02\u7814\u7a76\u7d50\u679c\u5df2\u65bc2021\u5e741\u6708\u7dda\u4e0a\u767c\u8868\u65bc\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a42.1\uff09\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u65e2\u5f80\u5316\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u6301\u4e45\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u60a3\u8005ORR\u70ba20.5%\uff0cDoR\u70ba12.8\u500b\u6708\uff0c\u4e2d\u4f4dOS\u905417.4\u500b\u6708\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u5168\u7403\u56db\u5927\u6d32\u8d85\u904e35\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u6279\u591a\u9805\u9069\u61c9\u75c7\uff0c\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u4e2d\u570b\u9999\u6e2f\u3001\u7f8e\u570b\u3001\u6b50\u76df\u3001\u82f1\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u5370\u5ea6\u3001\u7d04\u65e6\u7b49\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/4-nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">2. 2025NCCN \u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff1a\u982d\u9838\u90e8\u816b\u7624\uff082025.V1\uff09.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u4f5c\u70ba\u6211\u570b\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u500b\u570b\u7522\u4ee5PD-1\u70ba\u9776\u9ede\u7684\u55ae\u6297\u85e5\u7269\uff0c\u7372\u5f97\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\u5c08\u6848\u652f\u6301\uff0c\u4e26\u69ae\u81ba\u570b\u5bb6\u5c08\u5229\u9818\u57df\u6700\u9ad8\u734e\u9805\u201c\u4e2d\u570b\u5c08\u5229\u91d1\u734e\u201d\u3002<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u81f3\u4eca\u5df2\u5728\u5168\u7403\uff08\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u53ca\u6771\u5357\u4e9e\u7b49\u5730\uff09\u958b\u5c55\u4e86\u8986\u84cb\u8d85\u904e15\u500b\u9069\u61c9\u75c7\u768440\u591a\u9805\u7531\u516c\u53f8\u767c\u8d77\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u6b63\u5728\u9032\u884c\u6216\u5df2\u5b8c\u6210\u7684\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u5728\u591a\u500b\u7624\u7a2e\u7bc4\u570d\u5167\u8a55\u4f30\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u5b89\u5168\u6027\u53ca\u7642\u6548\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9f3b\u54bd\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u814e\u764c\u53ca\u76ae\u819a\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u5167\u5730\u7372\u627910\u9805\u9069\u61c9\u75c7\uff1a\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7642\uff082018\u5e7412\u6708\uff09\uff1b\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7642\uff082021\u5e742\u6708\uff09\uff1b\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u5305\u62ec\u65b0\u8f14\u52a9\u6216\u8f14\u52a9\u5316\u764212\u500b\u6708\u5167\u9032\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7642\uff082021\u5e744\u6708\uff09\uff1b\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u5c40\u90e8\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082021\u5e7411\u6708\uff09\uff1b\u806f\u5408\u7d2b\u6749\u9187\u548c\u9806\u9251\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u5fa9\u767c\u6216\u9060\u8655\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082022\u5e745\u6708\uff09\uff1b\u806f\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u9251\u985e\u7528\u65bc\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4\uff08EGFR\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9670\u6027\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff082022\u5e749\u6708\uff09\uff1b\u806f\u5408\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\uff0c\u7e7c\u4e4b\u672c\u54c1\u55ae\u85e5\u4f5c\u70ba\u8f14\u52a9\u6cbb\u7642\uff0c\u7528\u65bc\u53ef\u5207\u9664IIIA-IIIB\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u6210\u4eba\u60a3\u8005\uff082023\u5e7412\u6708\uff09\uff1b\u806f\u5408\u963f\u6614\u66ff\u5c3c\u7528\u65bc\u4e2d\u9ad8\u5371\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u814e\u7d30\u80de\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082024\u5e744\u6708\uff09\uff1b\u806f\u5408\u4f9d\u8a17\u6cca\u82f7\u548c\u9251\u985e\u7528\u65bc\u5ee3\u6cdb\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\uff082024\u5e746\u6708\uff09\uff1b\u806f\u5408\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7d50\u5408\u578b\uff09\u7528\u65bc\u7d93\u5145\u5206\u9a57\u8b49\u7684\u6aa2\u6e2c\u8a55\u4f30PD-L1\u967d\u6027\uff08CPS\u22651\uff09\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff082024\u5e746\u6708\uff09\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u9996\u6b21\u901a\u904e\u570b\u5bb6\u91ab\u4fdd\u8ac7\u5224\uff0c\u76ee\u524d\u5df2\u670910\u9805\u7372\u6279\u9069\u61c9\u75c7\u7d0d\u5165\u300a\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff082024\u5e74\uff09\u300b\uff0c\u662f\u76ee\u9304\u4e2d\u552f\u4e00\u7528\u65bc\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u570d\u624b\u8853\u671f\u3001\u814e\u764c\u3001\u4e09\u9670\u6027\u4e73\u817a\u764c\u6cbb\u7642\u7684\u6297PD-1\u55ae\u6297\u85e5\u7269\u30022024\u5e7410\u6708\uff0c\u7279\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